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KMID : 0605720140200030219
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Journal of the Korean Society of Biological Therapies in Psychiatry
2014 Volume.20 No. 3 p.219 ~ p.226
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The Relationship between the Amisulpride - Induced Weight Gain and the Dopamine D2 Receptor Genes Polymorphisms(rs1800497) in Schizophrenia Patients
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Seo Min-Jae
Woo Jung-Min
Lee Jong-Hun
Choi Tae-Young
Kim Ji-Hyun
Choi Sung-Min
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Abstract
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Objectives：The aim of this study is to evaluate the association between antipsychotics-induced weight gain and the polymorphisms in the dopamine receptor D2(DRD2) genes.
Methods：We measured the weight and height of 125 schizophrenia patients before and after treatment. The genotyping for rs1800497 was performed using TaqMan single nucleotide polymorphism(SNP) genotyping assay.
Results：There was a significant difference in the amisulpride-induced change of body mass index(BMI) according to the frequency of rs1800497 genotype.
Conclusion：This is the first positive association study between DRD2 gene and the amisulpride induced weight gain in
Korean schizophrenia patients. A larger scale research on more SNP of the DRD2 gene will make a progress in the study of amisulpride induced weight gain.
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KEYWORD
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Amisulpride, DRD2 gene, Polymorphisms, Weight gain
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